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Used alone or in combination withparomomycin, SSG is still a 1st line drug in East Africa, CentralAsia and South America. They areresponsible for attachinglongbundles ofactinfilaments (stressfibers) into the basal lamina (Fig They areresponsible for attachinglongbundles ofactinfilaments (stressfibers) into the basal lamina (Fig. Like type I cells, type III epithelioreticularcells create a functional barrier—in this case, between thecortex and medulla. Threemajor mechanisms for this loop interruption have been identied; rst, stressinduces post-translational modications of both p53 and Mdm2; second, interactingproteins act to disrupt p53/Mdm2 binding; third, transportation of the two proteinsleads to their spatial separation Threemajor mechanisms for this loop interruption have been identied; rst, stressinduces post-translational modications of both p53 and Mdm2; second, interactingproteins act to disrupt p53/Mdm2 binding; third, transportation of the two proteinsleads to their spatial separation.